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Natural Heart Health Product #1
Article One: Magnesium is essential to heart health.

Magnesium keeps the heart relaxed during stress. A major cause of heart attack in the US is stress. Do you know why stress induces heart attacks? Both calcium and magnesium are involved in each heart beat. Calcium signals the heart to contract and magnesium signals the heart to relax. So each beat of your heart involves both calcium and magnesium.

The average person has generous amounts of calcium available for use from their diet; magnesium, however, is less readily available. Our soils are very low in magnesium which means our food has very little magnesium. In addition, stress uses up the little magnesium we do have in our body. Without adequate magnesium the heart starts to cramp, and we call that a heart attack.

According to Dr. Mildred S. Seelig, who wrote
The Magnesium Factor, seven out of ten people are low in magnesium. That's a serious problem when it comes to the heart.

Did you know that when a person ends up in an ambulance or an emergency room with a heart attack the EMT's or the physician on call will give them an injection of magnesium? Why? Because magnesium will immediately cause their heart to relax.

Benefits of Magnesium for the heart:

Clot prevention:
powerfully prevents platelet clumping
Reduce the chance of atrial fibrillation and cardiac arrhythmia (irregular heartbeat)
http://www.umm.edu/altmed/articles/magnesium-000313.htm
Strong blood vessel dilation - Transdermal Magnesium Therapy by Mark Sircus
Natural calcium channel blocker - without side effects -- Intelligent Medicine: A Guide to Optimizing Health and Preventing Illness for the Baby-Boomer Generation by Ronald L. Hoffman, M.D.
Prevents atherosclerosis -- Natural Medicine, Optimal Wellness: The Patient's Guide to Health and Healing by Jonathan V. Wright, M.D. and Alan R. Gaby, M.D.
Lowers cholesterol - The Natural Pharmacy: Complete Home Reference to Natural Medicine by Schuyler W. Lininger, Jr. DC
Regulates body temperature - Dunne, Lavon J. (1990). Nutrition Almanac. New York: McGraw-Hill, p. 78.

One well-designed study found that taking magnesium orotate for a year reduced symptoms and improved survival rates compared to placebo in people with CHF. http://www.umm.edu/altmed/articles/magnesium-000313.htm

Many studies show magnesium deficiency is an underlying cause of mitral valve prolapse. http://www.ncbi.nlm.nih.gov/pubmed/3079420 - http://www.ncbi.nlm.nih.gov/pubmed/3014234

CAUTION: Magnesium salts may decrease the absorption of other drugs taken at the same time such as digoxin, tetracycline, iron and phenytoin. People with kidney problems and some heart diseases should not take large doses of magnesium. - The New Encyclopedia of Vitamins, Minerals, Supplements and Herbs by Nicola Reavley

Am Heart J, 102 Aug;124(2):544-9 - Magnesium deficiency and sudden death Mark J. Eisenberg, MD, MPH San Francisco, Calif.

Studies of Minerals and Cardiac Health in Selected Populations, Floyd J. Frost Lovelace Respitory Research Institute ILSI Format (Agutst 13, 2004)

Myocardial injury in magnesium deficiency Magnesium in Health and Disease: Y. Itokawa & J. Durlach, eds. © 1989 John Libbey & Co Ltd. pp 191-197.

Adv. Cardiol., vol. 25, pp. 9-24 (Karger, Basel 1978) Minerals, Coronary Heart Disease and Sudden Coronary Death Supported in part by the Yrjö Jahnsson Foundation, Helsinki, and Medipolar Oy, Oulu (Finland).H. KARPPANEN, R. PENNANEN and L. PASSINEN

Journal of Nutritional Medicine (1994) 4, 169-177 CLINICAL EXPERIENCE The Case for Intravenous Magnesium Treatment of Arterial Disease in General Practice: Review of 34 Years of Experience S. E. BROWNE MB BCH 17 The Close, Wilmington, Dartford, Kent DA2 7ES, UK

Intravenous Magnesium in Arterial Disease, S. E. Browne

"Minimum Magnesium Standard for Drinking and Bottled Water Would Save 150,000 Lives Annually" This article is by Bill Sardi and appeared in the May 1999 issue of the Townsend Letter for Doctors and Patients. *WATER*

The Magnesium Report, Clinical, Research, and Laboratory News for Cardiologists December 1999 Oral Magnesium for Cardiac Arrhythmias: Current Clinical Perspective EZRA A. AMSTERDAM, MD

Magnesium and Potassium in Lone Atrial Fibrillation, Patrick Chambers, M.D. and VMAFer vagally mediated atrial fibrillation February, 2003

The Role of Magnesium in the Prevention of Coronary Disease and Other Disorders "Magnesium deficiency is very common in this country and may be the single most correctable factor to prevent heart and other diseases."

"Calculations of American Deaths Caused by Magnesium Deficiency, As Projected From International Data" A summary of what Mg does for you, suitable for both laymen and professionals.

"Cardio-protective Contribution of Hard Waters to Magnesium Intake" by J. R. Marier.

Cardiovascular Consequences of Magnesium Deficiency and Loss: Pathogenesis, Prevalence and Manifestations--Magnesium and Chloride Loss in Refractory Potassium Repletion; American Journal of Cardiology 63:4G-21G, 1989.
Magnesium
Maintain a healthy weight

As you put on weight in adulthood, your weight gain is mostly fat rather than muscle. This excess weight can lead to conditions that increase your chances of heart disease — high blood pressure, high cholesterol and diabetes.

One way to see if your weight is healthy is to calculate your body mass index (BMI), which considers your height and weight in determining whether you have a healthy or unhealthy percentage of body fat. BMI numbers 25 and higher are associated with higher blood fats, higher blood pressure, and an increased risk of heart disease and stroke.

The BMI is a good, but imperfect guide. Muscle weighs more than fat, for instance, and women and men who are very muscular and physically fit can have high BMIs without added health risks. Because of that, waist circumference also is a useful tool to measure how much abdominal fat you have:
Men are considered overweight if their waist measurement is greater than 40 inches (101.6 centimeters, or cm)
Women are overweight if their waist measurement is greater than 35 inches (88.9 cm)

Even a small weight loss can be beneficial. Reducing your weight by just 10 percent can decrease your blood pressure, lower your blood cholesterol level and reduce your risk of diabetes.

From: Mayo Clinic

Seven out of ten people are low in magnesium.
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Article Two: Magnesium orotate is a mineral salt that is normally found in small amounts in all living things. Each molecule of magnesium orotate consists of two molecules of orotic acid in which a single magnesium atom replaces a pair of hydrogen atoms (one from each orotic acid molecule).

Orotate (orotic acid) is a biochemical substance made by all living cells. It is a necessary raw material for making the genetic material: RNA and DNA.4

Magnesium is an essential mineral that serves as a cofactor for many enzymes made in the body.1 The optimum dietary magnesium intake for humans is still being disputed. Some authorities give a range of 30 to 400 mg/day depending upon age,2 while others believe it is more like 400 to 1000 mg/day.3

Of the minerals required in large amounts by the human body, the one most likely to be deficient is magnesium.5 Various disorders have been linked to magnesium deficiencies, including cardiovascular disease, diabetes, high blood pressure, anxiety disorders, dementia, migraines and osteoporosis.1 In addition, physicians have found magnesium compounds helpful for treating asthma, chronic lung disease, and cardiac conditions such as heart attack and arrhythmias.5
What we can’t tell you

In the U.S. and some other industrialized countries, government agencies like the U.S. Food and Drug Administration have adopted censorship as a method for intensifying their control over supplement users and their suppliers. Thus, FDA regulations prohibit us from telling you that any of our products are effective as medical treatments, even if they are, in fact, effective.

Accordingly, we will limit our discussion of magnesium orotate to a brief summary of relevant research, and let you draw your own conclusions about what medical conditions it may be effective in treating.

Magnesium orotate was introduced as a supplement by Dr. Hans Nieper, the innovative German physician,6 who used it to treat or prevent the following conditions:5,7
atherosclerosis
kidney failure from diabetes or high blood pressure
viral diseases
heart attacks
blood clots

Nieper considered orotates to be superior to carbonates, chlorides, sulfates, and other anions as bioavailability enhancers for minerals like magnesium.5

Hans Nieper was a controversial figure whose treatments were denounced by many in the medical profession and were targeted by the U.S. Food and Drug Administration — despite the fact that these critics had done essentially no investigation of these treatments, and despite the fact that countless thousands of Nieper’s patients and followers found the treatments to be superbly effective.6 Nieper died in 1998, but his influence lives on.

Other researchers have also studied some of the medical applications of magnesium ororate. Let’s look briefly at these applications.
Recovery from heart attacks and heart surgery

A substantial number of studies have been done using magnesium orotate supplements for patients who have had heart attacks or heart surgery. The main benefits reported include: improved survival of tissue damaged by oxygen starvation,8 reduction of premature heartbeats,9 increase in exercise capacity,9,10 correction of magnesium depletion,11 improvements in skin appearance,12 and reduction in calcification of damaged heart tissue.13 The mechanism for these benefits is suspected to involve an improved availability of DNA and RNA precursors needed for repair of damaged tissue, and an increase in the synthesis of glycogen and ATP, both of which provide energy to the heart muscle.14
Magnesium orotate and athletic performance

Since magnesium orotate has been shown to improve the performance of heart muscle in patients who have had heart attacks, and apparently does so by improving the heart muscle’s access to energy, it is not surprising that similar results have been seen in studies in which the subjects were athletes rather than patients. For example, a 1998 study reported that “... 23 competitive triathletes competing in an event consisting of a 500-meter swim, a 20-km bicycle race, and a 5-km run were studied after 4-week supplementation with placebo or 17 mmol/d Mg orotate. ... Swimming, cycling, and running times decreased in the Mg-orotate group compared with the controls.”15
Cardiovascular disease and cholesterol profiles

As science writer Ed Sharpe has pointed out, magnesium orotate has been reported to improve the elasticity of blood vessels. A daily dose of 380 mg magnesium orotate over 15 months was sufficient to normalize or greatly improve the elasticity of peripheral blood vessels in 60 of 64 of Hans Nieper’s patients.“Such an effect on vessel elasticity suggests the use of magnesium orotate for lowering blood pressure as well as for inhibiting arteriosclerosis.”5

Hungarian studies during the 1990s found that magnesium orotate influenced LDL and HDL cholesterol levels in the arteries of rabbits and inhibited plaque formaiton.16 “Atherosclerotic alterations in each vessel could be influenced moderately by Mg-chloride, quite well by orotic acid and excellently by Mg-orotate. From these results one can conclude that orotic acid and Mg-orotate have a beneficial effect in the prevention and therapy of heart and vessels diseases.”17
In combination with potassium orotate

Hans Nieper usually combined magnesium orotate with other supplements to take advantage of synergies. For example, he recommended a combination of magnesium orotate (1.5 to 2.5 grams per day) plus potassium orotate (138 to 300 mg daily) for treating coronary heart disease. He also suggested adding the pineapple enzyme bromelain (120 to 140 mg per day) to inhibit platelet aggregation and dissolve fibrin clots. In this way he reduced the mortality rates by 90% or more compared to patients in other studies who received conventional medications.5
Attention deficit hyperactivity disorder (ADHD)

The main symptoms of ADHD are inattention, instability, and physical aggression with no self-control. Children with ADHD have significantly lower-than-normal magnesium levels in red blood cells.18 In a 2004 study of 52 hyperexcitable children, intervention for six months with magnesium and vitamin B6 (pyridoxine) reduced hyperactivity, hyperexcitability, and aggressiveness in all treated patients and improved school attention.18,19
Autism

Autism, a neurodevelopmental disorder, is characterized by three behavioral impairments: impaired social interaction, impaired communication, and restricted and repetitive interests and activities.20 According to a recent online survey, approximately 30% of parents give their autistic children a supplement of magnesium and vitamin B6.21 There is no agreement of what dosages of magnesium and vitamin B6 should be used.

In a recent study French researchers showed that children with autism had significantly lower red blood cell magnesium levels than controls. Intervention with magnesium and vitamin B6 (pyridoxine) reduced autistic symptoms in 23 children out of 33, stereotyped restricted behavior in 18 children, and abnormal/delayed functioning in 17 children. It improved social interactions in 23 children and communication in 24 children.22
Review articles

For a good introductory discussion of mineral salts and other related mineral transporters, see the review Mineral chelates, salts and colloids by Alvin Hashimoto.23 For an explanation of possible mechanisms through which orotates operate in the body, see the article How orotates work: The biochemistry of ‘vitamin B13’ by Ed Sharpe.24 An overview of magnesium orotate usage for heart attack patients is found in Rosenfeldt’s 1998 review Metabolic supplementation with orotic acid and magnesium orotate.25
Conclusion

Are magnesium orotate supplements useful for the conditions and purposes mentioned above? We aren’t allowed to tell you, so you should take a look at some of the references cited here, and then decide for yourself.

References

[1] Magnesium: Compounds in living organisms Wikipedia website

[2] Magnesium supplements Vitamins-supplements.org website

[3] Magnesium and Aging DrLam.com website

[4] Nucleotide-metabolism: Pyrimidine Nucleotide Biosynthesis Indiana State University website

[5] Delano.com website Orotates and the mineral transporters of Dr. Nieper Ed Sharpe

[6] Delano.com website> About Hans Nieper, M.D. Russell Mills

[7] Avery Publishing Group; Garden City Park, NY (1999) The Curious Man: The Life and Works of Dr. Hans Nieper Hans A. Nieper, MD; Arthur D. Alexander, III; G.S. Eagle-Oden

[8] Magnesium orotate in myocardial and neuronal protection. Rom J Intern Med. 37(1):91-7 Zeana C

[9] Assessment of treatment with orotate magnesium in early postoperative period of patients with cardiac insufficiency and coronary artery by-pass grafts (ATOMIC). Rom J Intern Med. 37(3):287-96 (2006) Branea I, et al.

[10] Effects of magnesium orotate on exercise tolerance in patients with coronary heart disease. Cardiovasc Drugs Ther. 1998 Sep; 12 Suppl 2:153-6 Geiss KR, Stergiou N, Jester , Neuenfeld HU, Jester HG

[11] Magnesium orotate--experimental and clinical evidence. Rom J Intern Med. 2004; 42(3):491-501 Classen HG

[12] [New approaches to the treatment of patients with idiopathic mitral valve prolapse] Ter Arkh. 2000; 72(9):67-70

[13] Effect of orotic acid and magnesium orotate on the development and progression of the UM-X7.1 hamster hereditary cardiomyopathy. Cardiovasc Drugs Ther. 1998 Sep; 12 Suppl 2:189-95 Jasmin G, Proschek L

[14] Magnesium orotate — experimental and clinical evidence. Rom J Intern Med. 2004; 42(3):491-501 Classen HG

[15] On the significance of magnesium in extreme physical stress. Cardiovasc Drugs Ther. 1998 Sep; 12 Suppl 2:197-202 Golf SW, Bender S, Grüttner J

[16] [Course of the progression of experimentally induced arteriosclerotic vessel wall changes after treatment with magnesium orotate] . Arzneimittelforschung. 2000 Dec; 50(12):1071-7 Jellinek H, Takács

[17] Morphological aspects of the effects of orotic acid and magnesium orotate on hypercholesterolaemia in rabbits. Arzneimittelforschung. 1995 Aug; 45(8):836-42 Jellinek H, Takács E

[18] Magnesium VitB6 intake reduces central nervous system hyperexcitability in children. J Am Coll Nutr. 2004 Oct; 23(5):545S-548S Mousain-Bosc M, Roche M, Rapin J, Bali JP

[19] Magnesium: Supplementation Wikipedia website

[20] Autism Wikipedia website

[21] Internet survey of treatments used by parents of children with autism. Res Dev Disabil. 27(1):70-84 Green VA, Pituch KA, Itchon J, Choi A, O'Reilly M, Sigafoos J

[22] Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6. II. Pervasive developmental disorder-autism. Magnes Res. 2006 Mar; 19(1):53-62 Mousain-Bosc M, Roche M, Polge A, Pradal-Prat D, Rapin J, Bali JP

[23] Mineral chelates, salts and colloids Delano.com website Alvin Hashimoto

[24] How orotates work: The biochemistry of ‘vitamin B13’ Delano.com website Ed Sharpe

[25] Metabolic supplementation with orotic acid and magnesium orotate. Cardiovasc Drugs Ther. 1998 Sep; 12 Suppl 2:147-52
Rosenfeldt FL
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